Article no.5

Theoretical Basis of Optimal Therapy for Individual Patients in Chronic Myeloid Leukemia: A Mathematical ApproachResearch Paper, July 6, 2020 / Lorand Gabriel Parajdi

Published in Taylor & Francis Online, Journal of Interdisciplinary Mathematics 23(3), 669-690, DOI: 10.1080/09720502.2019.1681699,  2020.

  Paper is available on the Taylor & Francis Online, Journal of Interdisciplinary Mathematics website:

Authors: Lorand Gabriel Parajdi1, Radu Precup1, Delia Dima3, Vlad Moisoiu2,3 and Ciprian Tomuleasa31 Department of Mathematics, “Babeş–Bolyai” University, Cluj-Napoca, Romania2 IMOGEN Research Institute County Clinical Emergency Hospital, Cluj-Napoca, Romania3 Department of Hematology, “Ion Chiricuţă” Clinical Cancer Center, Cluj-Napoca, Romania

Abstract: Even if the successful pharmacological therapy for chronic myeloid leukemia has reached today a near normal life expectancy in a patient diagnosed with this malignancy, almost one in four patients will change the line of tyrosin-kinase inhibitors during therapy, may it be due to poor response of due to intolerance to therapy. In this paper, starting from a mathematical characterization of the chronic phase in myeloid leukemia, a theoretical investigation of optimal therapy is undertaken as base for further pharmaceutical research and personalized treatment protocols.

Subject Classification: 92B05, 92D25, 92C50

Keywords: Mathematical model; Chronic myeloid leukemia; Dynamic system; Optimization problem.

Cite As: Lorand Gabriel Parajdi, Radu Precup, Delia Dima, Vlad Moisoiu & Ciprian Tomuleasa (2020) Theoretical basis of optimal therapy for individual patients in chronic myeloid leukemia: A mathematical approach, Journal of Interdisciplinary Mathematics, 23:3, 669-690,  DOI: 10.1080/09720502.2019.1681699.

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