Subject: Biomathematics	Code: ME278	

Semester	 Hours: C+S+L	Type	 Section	
2	2+1+1	compulsory	Applied Mathematics	

Teaching Staff in Charge	Prof. PRECUP Radu, Ph.D., r.precup@math.ubbcluj.ro
Assoc.Prof. BUICA Adriana, Ph.D., abuica@math.ubbcluj.ro	
Aims	Main models from biology are presented	
Content	1. Population dynamics: single species models; Lotka-Volterra type models; equilibrium solutions; stability; hysteresis. 
2. Methods of nonlinear analysis: the fixed point theorems of Banach, Schauder and Leray-Schauder; methods of upper and lower solutions and monotone iteration principle; applications to a delay integral equation from biology.
3. Reaction-diffusion systems: conservation equation; reaction-diffusion mechanisms; Turing's theory on diffussion-driven instability; spatial pattern with reaction-diffusion mechanisms; applications in morphogenesis. 
4. Mathematical models in epidemiology: SIR models; methods of nonlinear analysis for the treatment of nonlinear equations from 
biomathematics; geographic spread of epidemics; travelling wave solutions.
	
Selective References	1. DIEKMANN O., DURRETT R., HADELER K., MAINI P., SMITH H.L. (eds.),  Mathematics inspired by biology, Springer, 1999.
2. LEUNG A.W., Systems of nonlinear partial differential equations. Applications to biology and engineering, Kluwer, 1989
3. BRAUER F., CASTILLO-CHAVEZ C., Mathematical models in population biology and epidemiology, Spinger, 2001
4. MURRAY J.D., Mathematical biology, Springer, 1987
5. PRECUP R., Lectii de ecuatii cu derivate partiale, Presa Universitara Clujeana, 2004 
6. PRECUP R., Methods in nonlinear integral equations, Kluwer, 2002
7. RASS L., RADCLIFFE J., Spatial deterministic epidemics, AMS, 200	
Assessment	written examinatio